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566 This is also an important mechanism of AD, leading to neurological dysfunction and disease progression

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Formulation Considerations GHK-Cu is generally best suited for gentle, water-based formulations and is typically avoided in highly acidic formulations containing: Strong exfoliating acids Low-pH formulations High-strength Vitamin C formulations Low-pH environments may destabilize the copper-peptide complex and influence formulation stability

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411,412,413,414 This effect is mediated by NAD + -dependent PARPs and SIRT1