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New Safety Signal: Dysesthesia The TRIUMPH-4 trial identified a previously unreported side effect called dysesthesia an abnormal sensation of touch where normal sensations feel unusual, uncomfortable, or mildly painful (like tingling, numbness, or "pins and needles")

Semaglutide belongs to a class of medications called glucagon-like peptide-1 (GLP-1) agonists

Black patients are less likely to receive recommendations for these drugs, even when they meet clinical criteria

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Because of these uncertainties, several leading medical organizations including the American Diabetes Association and Obesity Medicine Association have recommended against using non-FDA-approved compounded GLP-1s

What Is GLP-1 and Why Microdose It