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As it stands right now, it seems that Ozempic / semaglutide is more powerful than berberine as a GLP-1 agonist, while berberine (when dosed well enough) can compete with metformin in terms of glycemia and lipids

It's important to distinguish compounded semaglutide from unregulated powders sold as "generic Ozempic" and the like, which may be contaminated or counterfeit, said FDA spokesperson Amanda Hils

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The goal is to separate and remove the majority of unwanted impurities and by-products, truncated sequences, deletion peptides, side-reaction products, and unreacted reagents from the crude peptide mixture

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