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In either case, the fuel, so to speak, for the increase in sirtuin activity is NAD +

doi: 10.18632/aging.102736 126 LuJ.HouW.GaoS.ZhangY.ZongY

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Blood 125 , 284295 (2015)

Expression of the HRH4 gene is seen at high levels in the gastrointestinal tract, spleen, thymus, medullary cells, bone marrow and peripheral hematopoietic cells, including eosinophils, basophils, mast cells, T-cells, leukocytes and dendritic cells