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[PubMed] [Google Scholar] 24.Xu G, Lv ZW, Feng Y, Tang WZ, Xu GX
To determine the effects of stimulating TCA cycle activity, we treated hepatocytes with dichloroacetate, which stimulates substrate entry into the TCA cycle by inhibiting PDKs (Constantin-Teodosiu, Simpson, & Greenhaff, 1999
It is noteworthy that hybrids GG2[D u A u A u ] 9,10,11,12 ( 2 , 13 nM) and GG2[F u I u A u ] 22,23,24,25 ( 16 , 62 nM) which contain native side chains and shifted substitution pattern still preserve substantial affinity with GLP-1R, although with over a hundred fold loss compared to the native peptide
Key Takeaway: Glutathione doesn't just "clean" the liver
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