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By the day 21 of the study, however, the immobility time of the fluoxetine-cannabis group was significantly decreased compared with the cannabis only-treated group

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Further, the FDA-approved synthetic peptide bremelanotide, which is a naturally-occurring metabolite of MT-II, has been evaluated in clinical trials in a nasal spray format [31]

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doi: 10.1097/00004583-200102000-00008

They have also identified a plethora of pathological molecular and neuronal phenotypes observed in schizophrenia patients, confirming the translational significance of these pre-clinical models [6, 7]