The TriNetX platform has been used in retrospective cohort studies [25,26,27,28,29,30,31,32,33,34,35,36,37,38] including evaluating risk and health outcomes of patients with substance use disorders including CUD [25, 32, 35] and the associations of GLP-1RAs with cancer [37] and semaglutide with suicidal ideations [38]
This new Harvard analysis offers a reassuring message for women who discover they were taking Ozempic, Wegovy, Zepbound, Mounjaro, or another GLP-1 medication before realizing they were pregnant
Tune in to Primes Pharmacy Friends podcast episode on MASH to learn more
In future, it is likely that the clinical indications for GLP- 1RAs will expand, with pharmaceutical companies running various drug trials to substantiate a wider array of use cases, such as the reduction of cardiovascular risk and the treatment of chronic kidney disease
The dose-dependent increase in GI adverse events is consistent with GLP-1 receptor activation patterns seen with semaglutide and tirzepatide at comparable therapeutic levels
If long-term liquid storage is required, the solution must be aliquoted into single-use volumes before the initial freeze
