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GHK-Cu copper load is the constraint, and doubling it provides no additional benefit while increasing copper exposure unnecessarily

Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin

This makes it suitable for those who can't tolerate finasteride's side effects or prefer non-hormonal approaches

However, larger and long-term studies are warranted to generate more evidence

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Mihovil et al., 2009