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Recently, Nrf2-Gpx4 pathway activation was found to have the ability to significantly suppress ferritin formation (71)

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doi: 10.1016/j.dsx.2018.05.006 78

Phenformin was well tolerated up to high concentrations, which agrees with its previous use as an antidiabetic drug before it was withdrawn from the market in the 1970s due to more frequent fatal cases of lactic acidosis compared to the alternative antidiabetic metformin