Downstream analyses of count data were performed with Seurat v4.3.0
Cumulative weight loss typically reaches 3-4% by week 4
GIP Receptor Agonism (Metabolic Synergy): The GIP component works in tandem with GLP-1 to potentiate insulin release without the risk of hypoglycemia
Lipid rafts (or cholesterol-rich nanodomains) are regions within the plasma membrane where weak binding between cholesterol and other phospholipids allows specific protein interactions to occur (Saxena and Chattopadhyay, 2012), as well as for effective serotonin control of food intake and prevention of hyperphagia (van Galen et al., 2021)
Questions to Ask Yourself Before Committing: Medical Appropriateness: Do I meet BMI criteria (30+ or 27+ with comorbidities)
"That's very concerning, because these are treatments that are meant to be lifelong, just like treatments for hypertension, for diabetes and for any other condition you have," Caroline Apovian, co-director of the Center for Weight Management and Wellness at Brigham and Women's Hospital
