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Serious adverse events were low in all treatment groups across the PIONEER programme, but gastrointestinal adverse events were the most common reason for discontinuation affecting approximately 612% of Rybelsus patients vs roughly 5% of Januvia patients in PIONEER 3

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Despite these trends, access remains a major barrier, particularly for low-income individuals who are uninsured or underinsured, highlighting the need to bridge the gap of affordability in the future