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10.1212/01.WNL.0000048204.89346.30 Neurology 25 BurdickK

Tryptophan, the amino acid precursor to serotonin, is absorbed through the intestinal epithelium and competes with other large neutral amino acids for transport across the blood-brain barrier

Mitochondrial oxidative stress caused by iron overload in muscle, which is a hallmark of insulin resistance

Furthermore, we found that chronic hypoxia enhanced ceramide catabolism by inducing hypoxia-inducible factor (HIF)-2 and HIF-2-dependent transcriptional activation of alkaline ceramidase 2 (Acer2)

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Cells constantly replace worn out proteins and repair cell structures