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An 8-week trial of supervised weight reduction with low-energy diet showed a mean weight loss of 14.2 kg, and significant improvement was observed in individuals in the intervention group in forced expiratory volume at one second (FEV1), forced vital capacity (FVC), dyspnea, use of rescue medication, and number of exacerbations, compared with controls [42]

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Systemic injection of Ex-4 was also able to evoke reduced cocaine seeking by activating GLP-1R in the NAc and the VTA [66,67]

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