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Lancet 2021;397:173648.ArticlePubMed 101

The patient discovered that calcitonin gene-related peptide (CGRP) antagonists worked in opposition to GLP-1 agonists: as GLP-1 agonists stimulate calcitonin release

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However, despite the favourable effects on CVD factors, the trial did not demonstrate a significant reduction in cardiovascular outcomes

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