FDA-approved medications for Cushing's syndrome include osilodrostat (Isturisa), levoketoconazole (Recorlev), pasireotide (Signifor), and mifepristone (Korlym)the latter specifically indicated for hyperglycemia secondary to Cushing's syndrome
Risk ratios (RR) for hospitalization for heart failure estimates according to direct (DPP-4 inhibitors, GLP-1RA and SGLT-2 inhibitors against placebo) and indirect (DPP-4 inhibitors vs GLP-1RA or SGLT-2 inhibitors, and GLP-1RA vs SGLT-2 inhibitors) comparisons
Preclinical studies have demonstrated that GLP-1 receptor agonists can attenuate nicotine self-administration behaviors and reinstatement in rodents, suggesting a potential role in preventing relapse
c-Myc can induce DNA damage, increase reactive oxygen species, and mitigate p53 function: a mechanism for oncogene-induced genetic instability
The adequate management of GI AEs would potentially improve a patients experience while undergoing treatment with GLP-1 RA, preventing discontinuations secondary to GI AEs
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