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Introduction Angiotensin IV (Ang IV) is a small bioactive peptide in the renin-angiotensin system (RAS) formed after proteolytic degradation of angiotensin II (Ang II)

In the case of obesity, leptin increases, and adiponectin decreases, causing an onslaught of inflammatory cytokines

This article has been updated by The Pharmaceutical Journal team and reviewed by the expert authors to ensure it remains relevant and up to date, following its original publication in December 2025

Australia is forecast at 17.4% supported by remote-care demand and professional oversight

In general, leptin down-regulates orexigenic peptides, and up-regulates anorexigenic peptides, leading to a reduction in food intake