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While an 11.2 percent average weight loss is clinically significant, it trails behind the 13.7 percent average reduction seen with semaglutide and 20.2 percent with tirzepatide
Additionally, the GH release triggers hepatocytes to secrete IGF-1 which assists in the regulation of overall growth, cell death, and lipolysis [1]
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Shimizu, M
A meta-analysis of 21 clinical studies showed a weighted mean difference in body weight of 2.9 kg (95% confidence interval [CI] 3.6 to 2.2) with the maximum dose of each one of the GLP-1RAs [43]
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