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The majority of the mitochondrial pool of folate is THF and 10-formyl-THF with less than 10% being 5-methyl-THF and 5-formyl-THF

Each patient receives an assessment to determine the correct approach

Considering the well-documented gonadotoxicity of platinum-based chemotherapeutics and the growing evidence supporting the antioxidative and anti-inflammatory properties of MEL and GSH, this study aims to explore a novel therapeutic strategy to mitigate chemotherapy-related ovarian toxicity

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Details of cryo-EM data collection and refinement are shown in Table 2