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Upon titration of UNC10088, the WT NSD2 protein exhibited a higher percent association with the FBXO22 FIST domain than any of the NSD2 variants tested (K253W, K253D, K253E) (Supplementary Fig

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Mechanistic investigations associate these outcomes with signaling pathways involving vascular endothelial growth factor receptor-2 (VEGFR-2) and downstream Akt-eNOS activation, processes that collectively facilitate efficient muscle tissue remodeling (5)

That decline is part of why it's drawn research interest in the first place: if a molecule occurs naturally and its levels drop as tissue repair capacity drops, it becomes a reasonable candidate for studying repair signaling directly

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Both targeted and non-targeted data analysis was applied