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So far, it is hypothesized that (1) on-line benefits to stimulation might be the result of directly modulating Purkinje neuron activity, whereas off-line benefits may be the result from long-lasting changes to the activity of Golgi cells [267, 268], and (2) severe cerebellar atrophy with a major loss of neurons above a threshold is unlikely to respond well to non-invasive stimulation

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Critically, these findings remain largely confined to cellular and in vitro models

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