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Why Does the 503A Bulks List Exist

Indications: Huntington's Chorea (a hyperkinetic movement disorder) A drug of first choice for this condition Side Effects: Sedation Depression (suicidal tendencies) Parkinsonism symptoms Lacks the hypotensive & GI side effects of reserpine due to its selectivity for central VMAT2 Pharmacokinetics: * undergoes rapid hepatic metabolism involving carbonyl reductase and CYP2D6 to 2 active metabolites -dihydrotetrabenazine (-HTBZ) and -dihydrotetrabenazine (-HTBZ), with eventual renal elimination of metabolites the -HTBZ and -HTBZ metabolites are primarily responsible for the pharmacological & therapeutic effects produced by the parent prodrug Readily crosses the blood brain barrier & depletes cerebral monoamine stores

[DOI] [PMC free article] [PubMed] [Google Scholar] 82.Bellucci M., Bozzano F.M., Castellano C., Pesce G., Beronio A., Farshchi A.H., Limongelli A., Uccelli A., Benedetti L., De Maria A

Linkova, N.S., et al

Each capsule contains 500mg of Glutathione, a powerful antioxidant that helps reduce pigmentation, protect skin cells from oxidative damage, and improve overall tone and texture

American Journal of Obstetrics and Gynecology , 184(7), 1407-1413