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After 12 weeks, the mean PASI and DLQI had a statistically significant reduction

Srivastava flags the gastrointestinal side effectslike many of these medications, some people had nausea, diarrhea, constipation, and vomitingbut says that the robust weight loss makes this an attractive option for people with severe obesity who also have knee arthritis

Both forms require a prescription and medical supervision from a licensed healthcare provider

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Selenium supplementation has been shown to reduce the size of thyroid nodules and goiter in specific Se-deficient individuals, but further studies are required to confirm these findings conclusively [76]