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Why is losing visceral fat challenging
Depending on the decision of the safety group to proceed to a higher dose level, it was planned to escalate to 40 mg from week 5 (in the 40 and 60 mg cohorts), and to 60 mg from week 7 (in the 60 mg cohort)
With an excess of reducing equivalents, T cells are unable to activate the relevant redox kinases, which allows them to bypass the regulatory checkpoints of the G2/M cell cycle and enter unrestrained proliferation (21)
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