Diabetologia (2015) 58(11):258291.10.1007/s00125-015-3728-z 5 HareKJKnopFKAsmarMMadsbadSDeaconCFHolstJJet alPreserved inhibitory potency of GLP-1 on glucagon secretion in type 2 diabetes mellitus
DL: As we look to the future, we intend to measure new populations that include a mix of GLP-1s that have come to market since the initial study time period
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Taken together, these efficacy and safety observations suggest that, for older patients without CV disease with T2DM who are not at A1C target despite metformin monotherapy, it is reasonable to preferentially recommend a DPP-4 inhibitor rather than an SGLT2 inhibitor as add-on therapy
Thus, several microbiota-derived metabolites have been found to stimulate enteroendocrine L-cells producing GLP-1