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Although the use of first-generation uncouplers (e.g., dinitrophenol, DNP) was limited by significant toxicity, subsequent experimental studies and early clinical observations have highlighted the potential benefits of controlled mitochondrial uncoupling in both metabolic diseases and cancer (Goedeke and Shulman, 2021

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Retatrutide carries a unique side effect, dysesthesia (tingling or burning sensations), reported in roughly 20.9% of participants at the 12 mg dose, not observed with tirzepatide [3]

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10.1089/zeb.2009.0639 10 CoffinA

ALCAR serves as a carrier that shuttles fatty acids into the mitochondria