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People who are otherwise healthy may be less willing to accept these potentially serious adverse events. Using a random sample of 16 million patients from the PharMetrics Plus database, Sodhi and colleagues evaluated gastrointestinal adverse events among new users of GLP-1 agonists liraglutide (n = 4,144) or semaglutide (n = 613) between 2006 and 2020

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A boxed warning is the most serious safety warning issued by the FDA and not something to take lightly

On the other hand, authorities from the US FDA to European Medicine Agency (EMA) have studied the potential risk of suicidal thoughts and self-harm with the use of GLP-1 agonist medications

Age-related changes in organ structure and function observed in older adults resemble those seen in patients with pathological GH deficiency

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