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Western blot assay Cells (1 10 6 ) were grown to 7080% confluency and treated with DMSO control, (1S,3R)-RSL3 (RSL3, Catalog # 19,288, Cayman Chemical, MI) or Fer1 (Medchemexpress, NJ) as per the experiments

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Furthermore, several clinical studies demonstrated that glucagon-like peptide-1 receptor agonists (GLP-1RAs) can reduce the risk of dementia in T2DM patients by improving memory and learning and overcoming cognitive impairment [12]