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Polymorphisms of the UCP2 gene are associated with glomerular filtration rate in type 2 diabetic patients and with decreased UCP2 gene expression in human kidney

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In other words, without Parkin, PINK1 can induce lower mitophagy due to low basal mitochondrial ubiquitin levels, whereas Parkin can produce more ubiquitin substrates and induce robust and rapid mitophagy [48]

doi: 10.1002/adhm.202101819 60 PaciollaC.FortunatoS.DipierroN.ParadisoA.De LeonardisS.MastropasquaL.et al