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Notably, the same meta-analysis highlighted that liraglutide, particularly when compared to higher doses of semaglutide or tirzepatide, promoted weight loss without a clinically meaningful reduction in lean mass [77]
Various studies have implicated neuroinflammation and cytotoxic factors such as interleukins (ILs), nitric oxide (NO), reactive oxygen species (ROS), and tumor necrosis factor- (TNF-) in the neurodegenerative processes underlying PD (Joshi and Singh 2018)
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Tirzepatide produced a 21% average weight reduction in non-diabetics and was FDA approved for weight loss in 2023