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This sensitivity arises from the indole ring of Trp, which is characterized by a relatively large dipole moment both in the ground and excited states it extensively interacts with polar and charged groups in its environment, and whose photophysical properties are affected by surrounding residues, solvent exposure, and molecular motion (Lakowicz, 1983

most PCOS patients see noticeable changes after 46 weeks, with significant reductions by 12 weeks

Side effects Women facing persistent nausea, fatigue, or GI discomfort that with dose adjustments usually feel like trying a different medication

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J Clin Endocrinol Metab (2009) 94(1):818