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When dose reduction is appropriate Phase 3 trials include provisions for dose reduction: Gastrointestinal adverse events or inadequate oral intake may warrant stepping down to a lower dose level see Retatrutide Side Effects for incidence rates by dose BMI reaching 22 kg/m or below , or perceived excessive weight loss, allows dose reduction Treatment is discontinued at BMI 18.5 kg/m or below How Often and When to Take Retatrutide Injection frequency once weekly by subcutaneous injection, on the same day each week

VAT, visceral adipose tissue

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Patients with a history of reflux should be especially mindful when starting a GLP-1

Weight Loss with GLP-1 About the Treatment What is GLP-1 Treatment

however, residual confounding by baseline BMI, glycemic status, indication, and discontinuation timing remains difficult to exclude (137)