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How Your Body Responds to Tirzepatide at Different Dose Levels At lower doses (2.55 mg), tirzepatide primarily suppresses appetite and reduces food cravings by activating GLP-1 receptors in the brain's hunger centers

Data are presented as median (range)

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However GSTP did not affect HMGB1 expression at mRNA and protein levels (Figures 2C,D)

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This reinforces the concept of obesity as a chronic disease requiring ongoing management