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Of the 27 dogs: 22% had an elevated MMA value, indicative of vitamin B12 depletion at the tissue level

Lebers hereditary optic neuropathy: B12 supplementation can worsen the conditionconsult a specialist (MedlinePlus)

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Additionally to the glycine biosensor, we have also designed and built constructs constitutively expressing the GcvA transcription factor, GcvR transcription factor and pepD using the BBa_J23100 promoter found on the iGEM registry of Basic Biological Parts