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PMID: 26236730 Published Research Highlights Discovery 1973 Tripeptide Identified in Human Serum Pickart and Thaler first identified the GHK sequence in human plasma, discovering a tripeptide that prolonged survival of normal liver cells and stimulated growth in cell culture models

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The development of long-acting peptide analogs reflects a broader trend within peptide science, where structural engineering is used to optimize biological and pharmacokinetic properties