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Participants received tirzepatide 5 mg, 10 mg, or 15 mg once weekly or placebo for 72 weeks

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The compound demonstrates exceptional target selectivity, with no inhibition of related methyltransferases (DNMT1, PRMT3, COMT) or NAD+ salvage enzymes (NAMPT, SIRT1) at concentrations up to 600 M

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This titration process helps minimize side effects, but it also means that any appetite-related effects may not be noticeable right away