The only Phase I trial (NCT02465229) was withdrawn in 2016 before enrollment
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In the phase III SURPASS clinical trials in people with T2D, tirzepatide has shown superior reductions in glycosylated hemoglobin with 2362% of tirzepatide-treated participants achieving normoglycemia (glycosylated hemoglobin 0.1 for each of the PK parameters ( C max , AUC 0 , and apparent total body clearance) (Fig