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Observational human studies have provided preliminary signals that warrant further investigation

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A 2023 World Health Organization (WHO) systematic review and guideline on non-sugar sweeteners cautioned against their long-term use for weight control, noting limitations in the evidence base

Another metabolic product of intestinal bacteria, urolithins (UA), is produced through the conversion of dietary ellagitannins and ellagic acid by specific gut microbiota

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Similarly, the LEADER trial with liraglutide showed a 13% reduction in MACE in patients with type 2 diabetes and high cardiovascular risk