The mechanism: IGF-1 receptor activation in renal tubules increases sodium reabsorption, expanding plasma volume and driving fluid into interstitial spaces
Over 100,000 people in the United States, are affected
Starting at a low dose and gradually titrating upwards helps minimise these effects
Many patients are surprised to learn they've gained muscle mass while the scale drops, because muscle is denser than fat and weighs more by volume
Zou XH, Sun LH, Yang W et al (2020) Potential role of insulin on the pathogenesis of depression
Angiogenic programming of neoplastic tissue is a multidimensional process regulated by cancer cells in concert with a variety of tumour-associated stromal cells and their bioactive products, which encompass cytokines and growth factors, the extracellular matrix and secreted microvesicles