In recent years it has been shown that lipotoxicity may induce the release of extracellular vesicles (EVs) and affects (and is affected by) hypoxia, both of which play important roles in the progression of NAFLD (Fig
Carnitine deficiency may cause various health issues affecting heart and muscle function
Takahashi M, Ueda S, Misaki H, et al
The generated glutamate can directly participate in the synthesis of glutathione, or generate cysteine which is another substrate of glutathione synthesis through the coupled action of glutamate efflux mediated by SLC7A11 and cysteine uptake (Timmerman et al., 2013)
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doi: 10.1097/CJI.0b013e3181a28422 43 LiuLPoonRChenLFrescuraA-MMontuschiPCiabattoniGet al